The 300C-I mechanical stimulator is an automated electronic von Frey device with the added capability to measure and control both force and length at a single application point. The 300C-I takes the variability and awkwardness out of applying force with a handheld von Frey filament or with other handheld mechanical stimulators. Our computer-controlled mechanical stimulator removes the unavoidable hand tremor associated with both von Frey filaments and other electronic von Frey systems. This removes the associated variation in force application.

Aurora Scientific’s mechanical stimulator increases throughput by eliminating the need for multiple tests to determine threshold. The force application and timing of the stimulus is consistent and precise, thereby removing the variability associated with handheld devices.

The mechanical stimulator is capable of applying constant force for pre-set periods of time with the added functionality of adjusting force at pre-determined rates. It can be applied in any combination of length or force and can follow an arbitrary force or distance application curve so force application is not limited to simple force ramps.

The delivery of constant and repeatable force ensures that consistency is maintained between experiments, subjects and studies, thus reducing avoidable error in your data and improving the quality of your findings.

• quantify mechanosensitivity using computer-controlled stimuli
• evaluate the supra threshold mechano sensitivity
• measure the mechanical threshold without performing multiple tests
• suitable for in-vitro, in-situ and ex-vivo preparations
• force ranges: 50g, 100g
• superior resolution (to 0.03g)
• operates in any orientation
• prevents production of off-axis forces
• range of tips available (0.5, 0.8, 1, 1.5, 2, 3 mm diameter)
• application area remains constant at all forces

Customized 300C-I Facilitates Migraine Headache Research

CHALLENGE

In 2002 Dr. Dan Levy of Harvard University was studying the underlying mechanisms of migraine headaches and was looking for a method to reliably apply varying forces to sensory neurons innervating the dura mater of a rat.

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300C-I – Mechanical Stimulation of Rat Skin

CHALLENGE

In 1998 Dr. Woodbury approached us with a need to perform mechanical stimulation of rat skin stretched in a recording chamber. He needed a computer controlled mechanical stimulator that could produce controlled five second square waves of varying forces through a cylindrical indenter tip.

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Kumar, Siddarth. et al. “Viscoelastic characterization of the primate finger pad in vivo by microstep indentation and three-dimensional finite element models for tactile sensation studies .” Journal of Biomechanical Engineering 137.6 (2015): 061002.

Qi, Huixin et al. “Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.” The Journal of Neuroscience 34.12 (2014): 4345-4363.

Dieudonné, Alexandre et al. “Encoding properties of the mechanosensory neurons in the Johnston's organ of the hawk moth, Manduca sexta.” The Journal of Experimental Biology 217.17 (2014): 3045-3056.

Milenkovic, Nevena et al. “A somatosensory circuit for cooling perception in mice.” Nature Neuroscience17.11 (2014): 1560-1566.

Reed, Jamie L. et al. “Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex.” Journal of Neurophysiology 108.12 (2012): 3353-3369.

Jankowski, Michael P. et al. “Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.” The Journal of Neuroscience 32.49 (2012): 17869-17873.

Molliver, Derek C. et al. “The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.” Molecular Pain 7.1 (2011): 13.

Ge, Weiqing, and Partap S. Khalsa. “Encoding of compressive stress during indentation by group III and IV muscle mechano-nociceptors in rat gracilis muscle.” Journal of Neurophysiology 89.2 (2003): 785-792.

Bove, Geoffrey M., Daniel R. Robichaud, and Peter Grigg. “Three-dimensional load analysis of indentation stimulators.” Journal of Neuroscience Methods 123.1 (2003): 23-30.

Khalsa, Partap S., Ce Zhang, and Yi-Xian Qin. “Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.” Journal of Neurophysiology 83.5 (2000): 3049-3061.

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