The first and only research instrument for direct measurement of bone material properties in vivo. Empowering the world’s top laboratory and clinical researchers to measure the material aspects of bone quality for the first time ever.
OsteoProbe® RUO (research use only) is a portable handheld microindenter, measures the ability of bone material to resist indentation, unlike radiological methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure.
OsteoProbe® RUO uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi).
Every measurement taken is recorded in OsteoProbe’s software, providing the most accurate data.
No technical background is necessary to learn how to use OsteoProbe.
The first and only research instrument for direct measurement of bone material properties in vivo.
OsteoProbe® RUO measures and quantifies material properties of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current techniques provide detailed information about the mineral aspect but we suffer from limited information about the organic. Learn more about Bone Quality.
In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, researchers can measure and monitor longitudinal changes in the material quality of bone.
OsteoProbe® RUO uses Reference Point Indentation (RPI) technology to measure bone material’s ability to resist a localized force. Utilizing a probe specifically designed for percutaneous measurements, OsteoProbe penetrates soft tissue down to the bone surface (sans incision), establishing a local reference point. Once actuated, OsteoProbe measures the resistance to force and outputs a Bone Material Strength index (BMSi) score.
OsteoProbe® RUO was designed with the researcher in mind.
OsteoProbe® RUO allows quick and easy measurement of bone material property data without requiring extensive training. Simply attach a probe, connect a wire, and start taking measurements.
Learn more about using OsteoProbe® RUO.
OsteoProbe® RUO was invented to empower researchers with the tool they need to discover how genetics, disease, diet, exercise, and other triggers affect the quality of the bone tissue.
The bigger picture is that Reference Point Indentation was invented to enable scientists to discover better treatments, medical professionals can deliver better results, and people can live actively throughout their entire life. Learn more about the invention.
BioDent? 骨等組織參考點壓痕測試分析系統(tǒng)可以測量骨和其他組織的力學特性，具有離體測量和在體測量兩種模式，可以直接在活體動物上在體測試分析骨等組織等力學特性；能獲得以前無法獲得的臨床數(shù)據(jù)，如骨和其他組織的材料性質(zhì)，對骨等組織尤為適用。 OsteoProbe® RUO為便攜式在體/離體骨組織測量儀為BioDent? 骨等組織參考點壓痕測試分析系統(tǒng)手持版本
BioDent使用設計獨特的微探針在微米水平上對組織施壓。探針處于一個小套管內(nèi)部(圖2 A)，套管可在組織上或組織內(nèi)部建立參考點，然后便可測量軟、硬材料和生物材料的凹陷距離、相對剛度和能量耗散，從而**地檢測材料力學性質(zhì)(圖2 B)。在恒力工作模式下，BioDent測量探針相對于參考點移動的距離，作為在此壓力下材料發(fā)生的形變。在恒定距離工作模式（即將推出）下，BioDent測量使材料發(fā)生此種程度的形變時需要的力。
BioDent可臨床測量材料性質(zhì)作為健康或病變組織的指標。這些組織通常由不同的軟硬組織在微米尺度上組合形成（圖3），BioDent可在微米和毫米尺度上進行測量，以用于不同的生物材料。
OsteoProbe® RUO是在體測量骨組織材料性質(zhì)的**儀器，是實驗室和臨床研究中測量骨質(zhì)量的有力工具。OsteoProbe® RUO是一種便攜式單手操作微壓痕儀，與測量骨密度的放射性方法（X射線、DXA和CT）具有不同的原理，它使用參考點壓痕技術來檢測材料對局部壓力的抵抗性。
OsteoProbe® RUO使用特別設計的探針來進行皮下測量，無須切開組織。探針刺空軟組織達到骨表面建立一個參考點，當探針受力達到一個預先設定的閾值后會自動觸發(fā)更大的力進行測量。軟件會記錄下來凹陷深度和力之間的函數(shù)關系，然后用聚甲基丙烯酸甲酯作為參照材料進行校準來獲得BMSi（材料強度指數(shù)）。