The CleanPlex? Hereditary Cancer Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 66 genes associated with Pediatric Cancer.
CleanPlex®兒科癌癥專家組是一種預(yù)先設(shè)計(jì)和定制的,基于PCR /擴(kuò)增子的多重靶向測(cè)序(NGS)分析方法,旨在檢查與兒科癌癥相關(guān)的66個(gè)基因的種系變異或突變。該小組針對(duì)這些基因的所有外顯子區(qū)域和側(cè)翼內(nèi)含子序列。僅需10 ng DNA即可兼容測(cè)序就緒的文庫(kù),只需3個(gè)小時(shí)即可使用簡(jiǎn)化的工作流程進(jìn)行準(zhǔn)備。預(yù)先設(shè)計(jì)的面板經(jīng)過(guò)計(jì)算機(jī)優(yōu)化,可提供具有高目標(biāo)性能和高覆蓋均勻性的數(shù)據(jù),以確保有效利用測(cè)序讀數(shù)。
該產(chǎn)品是定做的。收到您的訂單后,我們將合成面板,該套件將包含CleanPlex Multiplex PCR引物和CleanPlex Targeted Library Kit。可以分別訂購(gòu)CleanPlex索引PCR引物和CleanMag®磁珠,以完成從輸入DNA到可測(cè)序的NGS文庫(kù)的工作流程。
貯存溫度
儲(chǔ)存在-20°C。
僅供研究使用。不用于診斷過(guò)程。
產(chǎn)品描述
AIP, ALK, APC, ATM, AXIN2, BAP1, BLM, BMPR1A, BUB1B, CDC73, CDKN1C, CEBPA, DICER1, DIS3L2, EPCAM, ETV6, EXT1, EXT2, FH, GATA2, GPC3, HRAS, KIF1B, LZTR1, MAX, MEN1, MLH1, MSH2, MSH6, NBN, NF1, NF2, PAX5, PHOX2B, PMS2, PRF1, PRKAR1A, PTCH1, PTCH2, PTEN, RB1, RECQL4, REST, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, SRP72, STK11, SUFU, TERC, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1
References:
Ahmed AA, et al. Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects. High Throughput. 2018;7(4):39.
Khater F, et al. Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers. JAMA Netw Open. 2019;2(4):e192906.
Khan J, et al. Precision Therapy for Pediatric Cancers. JAMA Oncol. 2016;2(5):575–577.
Kuhlen M, et al. Family-based germline sequencing in children with cancer. Oncogene 38, 1367–1380 (2019).
Maese L, et al. The evidence for expanded genetic testing for pediatric patients with cancer. Future Oncol. (2018) 14(3), 187–190
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